BAIT

FBXW7

AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GO Process (24)
GO Function (6)
GO Component (6)
Homo sapiens
PREY

VPS16

hVPS16, RP11-12M19.2
vacuolar protein sorting 16 homolog (S. cerevisiae)
GO Process (3)
GO Function (1)
GO Component (6)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X

The tumor suppressor FBW7 is the substrate recognition component of the SCF E3-ubiquitin ligase complex that mediates proteolytic degradation of various oncogenic proteins. However, the role of FBW7 in ovarian cancer progression remains inadequately understood.IP-MASS, co-IP, immunohistochemistry, and western blotting were used to identify the potential substrate of FBW7 in ovarian cancer. The biological effects of FBW7 were investigated using ... [more]

Mol Cancer Dec. 03, 2020; 20(1);45 [Pubmed: 33658012]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
FBXW7 VPS16
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
1518042

Curated By

  • BioGRID