BAIT
PDIA6
ERP5, P5, TXNDC7
protein disulfide isomerase family A, member 6
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DDX3X
D1Pas1-rs2, Ddx3, Fin14, RP23-158L19.4
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
GO Process (27)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- RNA secondary structure unwinding [ISO]
- cellular response to arsenic-containing substance [ISO]
- cellular response to osmotic stress [ISO]
- chromosome segregation [ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- innate immune response [ISO]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- mature ribosome assembly [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of translation [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of translation [ISO]
- positive regulation of translational initiation [ISO]
- positive regulation of viral genome replication [ISO]
- response to virus [ISO]
- stress granule assembly [ISO]
Gene Ontology Molecular Function- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent RNA helicase activity [ISO]
- ATPase activity [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA stem-loop binding [ISO]
- eukaryotic initiation factor 4E binding [ISO]
- mRNA 5'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- poly(A) binding [ISO]
- protein binding [IPI]
- ribosomal small subunit binding [ISO]
- transcription factor binding [ISO]
- translation initiation factor binding [ISO]
- ATP-dependent DNA helicase activity [ISO]
- ATP-dependent RNA helicase activity [ISO]
- ATPase activity [ISO]
- DNA binding [ISO]
- RNA binding [ISO]
- RNA stem-loop binding [ISO]
- eukaryotic initiation factor 4E binding [ISO]
- mRNA 5'-UTR binding [ISO]
- poly(A) RNA binding [ISO]
- poly(A) binding [ISO]
- protein binding [IPI]
- ribosomal small subunit binding [ISO]
- transcription factor binding [ISO]
- translation initiation factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.
RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities. ... [more]
Nucleic Acids Res Dec. 09, 2020; 49(12);6702-6721 [Pubmed: 34133714]
Throughput
- High Throughput
Additional Notes
- Included protein pairs with sumIS score >= 7.1
Curated By
- BioGRID