BAIT

PUM2

5730503J23Rik, Pumm2, mKIAA0235
pumilio RNA-binding family member 2
GO Process (1)
GO Function (3)
GO Component (6)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

SRSF8

DSM-1, SFRS2B, SRP46
serine/arginine-rich splicing factor 8
GO Process (0)
GO Function (2)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

Lang B, Yang JS, Garriga-Canut M, Speroni S, Aschern M, Gili M, Hoffmann T, Tartaglia GG, Maurer SP

RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities. ... [more]

Nucleic Acids Res Dec. 09, 2020; 49(12);6702-6721 [Pubmed: 34133714]

Throughput

  • High Throughput

Additional Notes

  • Included protein pairs with sumIS score >= 7.1

Curated By

  • BioGRID