BAIT
PTCH1
A230106A15Rik, Ptc, Ptc1, Ptch, mes
patched homolog 1
GO Process (48)
GO Function (10)
GO Component (12)
Gene Ontology Biological Process
- brain development [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- cell differentiation involved in kidney development [IGI]
- cell proliferation involved in metanephros development [IMP]
- cellular response to cholesterol [ISO]
- dorsal/ventral neural tube patterning [IMP]
- dorsal/ventral pattern formation [IGI]
- embryonic limb morphogenesis [IGI, IMP]
- embryonic organ development [IGI]
- epidermis development [IMP]
- glucose homeostasis [IMP]
- heart morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- in utero embryonic development [IGI]
- keratinocyte proliferation [IMP]
- limb morphogenesis [ISO]
- mammary gland development [IMP]
- mammary gland duct morphogenesis [IMP]
- mammary gland epithelial cell differentiation [IMP]
- negative regulation of cell division [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of multicellular organism growth [IMP]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of smoothened signaling pathway [IGI, IMP, NAS]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neural plate axis specification [IMP]
- neural tube closure [IMP]
- neural tube formation [IDA]
- neural tube patterning [ISO]
- organ morphogenesis [IMP]
- pattern specification process [IMP]
- pharyngeal system development [ISO]
- positive regulation of cholesterol efflux [ISO]
- protein processing [IMP]
- protein targeting to plasma membrane [ISO]
- regulation of cell proliferation [IMP]
- regulation of growth [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of protein localization [IDA, IMP]
- regulation of smoothened signaling pathway [IGI, IMP]
- response to chlorate [IDA]
- signal transduction [IDA, TAS]
- smoothened signaling pathway [IDA, IGI]
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IMP]
- somite development [IMP, ISO]
- spinal cord motor neuron differentiation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axonal growth cone [ISO]
- caveola [ISO]
- dendritic growth cone [ISO]
- extracellular region [TAS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [ISO]
- midbody [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [IDA]
Mus musculus
PREY
ADCYAP1
PACAP
adenylate cyclase activating polypeptide 1
GO Process (36)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- ATP metabolic process [ISO]
- activation of adenylate cyclase activity [TAS]
- behavioral fear response [ISO]
- cAMP-mediated signaling [ISO]
- histamine secretion [ISO]
- intracellular signal transduction [IDA]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of acute inflammatory response to antigenic stimulus [ISO]
- negative regulation of acute inflammatory response to non-antigenic stimulus [ISO]
- negative regulation of cell cycle [IDA]
- negative regulation of glial cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of potassium ion transport [ISO]
- neuron projection development [ISO]
- neuropeptide signaling pathway [ISO, TAS]
- ovarian follicle development [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of Rap GTPase activity [ISO]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of growth hormone secretion [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of somatostatin secretion [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of vasodilation [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [ISO]
- regulation of oligodendrocyte progenitor proliferation [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of protein localization [IDA, ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.
Hedgehog (Hh) proteins and cAMP-dependent protein kinase A (PKA) generally play opposing roles in developmental patterning events. Humans and mice heterozygous for mutations in the sonic hedgehog (Shh) receptor gene patched-1 (ptc1) have an increased incidence of certain types of cancer, including medulloblastoma (MB), a highly aggressive tumor of the cerebellum. Despite the importance of PKA in Hh signaling, little ... [more]
Dev Biol Jan. 01, 2008; 313(1);359-70 [Pubmed: 18036580]
Throughput
- Low Throughput
Curated By
- BioGRID