BAIT
GNB2L1
AL033335, GB-like, Gnb2-rs1, Rack1, p205, RP23-14F5.6
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
GO Process (23)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- intracellular signal transduction [ISA]
- negative regulation of cell growth [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of hydrogen peroxide-induced neuron death [ISO]
- negative regulation of phagocytosis [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- negative regulation of translation [ISO]
- osteoblast differentiation [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cAMP catabolic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cyclic-nucleotide phosphodiesterase activity [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial depolarization [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein homooligomerization [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein localization [ISA]
- regulation of cell cycle [ISO]
- regulation of establishment of protein localization to plasma membrane [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
- SH2 domain binding [ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISO]
- enzyme binding [ISO]
- ion channel inhibitor activity [IDA]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISA, ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase inhibitor activity [ISO]
- receptor activity [ISA]
- receptor tyrosine kinase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
G3BP2
AA409541, E430034L04Rik, G3BP, mKIAA0660
GTPase activating protein (SH3 domain) binding protein 2
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.
RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities. ... [more]
Nucleic Acids Res Dec. 09, 2020; 49(12);6702-6721 [Pubmed: 34133714]
Throughput
- High Throughput
Additional Notes
- Included protein pairs with sumIS score >= 7.1
Curated By
- BioGRID