BAIT
EIF2S1
0910001O23Rik, 2410026C18Rik, 35kDa, Eif2a, eIF2alpha
eukaryotic translation initiation factor 2, subunit 1 alpha
GO Process (4)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SRSF6
1210001E11Rik, AI314910, AW146126, Sfrs6, RP23-206I14.4
serine/arginine-rich splicing factor 6
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- alternative mRNA splicing, via spliceosome [ISO]
- mRNA splice site selection [ISO]
- negative regulation of cell death [ISO]
- negative regulation of keratinocyte differentiation [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [ISO]
- regulation of alternative mRNA splicing, via spliceosome [ISO]
- regulation of keratinocyte proliferation [ISO]
- regulation of wound healing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.
RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs are often poor predictors of RBP-RNA interactions in vivo. It is hence believed that many RBPs recognize RNAs as complexes, to increase specificity and regulatory possibilities. ... [more]
Nucleic Acids Res Dec. 09, 2020; 49(12);6702-6721 [Pubmed: 34133714]
Throughput
- High Throughput
Additional Notes
- Included protein pairs with sumIS score >= 7.1
Curated By
- BioGRID