BAIT
APP
Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp
amyloid beta (A4) precursor protein
GO Process (38)
GO Function (10)
GO Component (27)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
Mus musculus
PREY
ATP2B2
D6Abb2e, Gena300, PMCA2, Tmy, dfw, jog, wms, wri
ATPase, Ca++ transporting, plasma membrane 2
GO Process (31)
GO Function (9)
GO Component (12)
Gene Ontology Biological Process
- ATP catabolic process [IMP]
- auditory receptor cell stereocilium organization [IMP]
- cGMP metabolic process [IMP]
- calcium ion export [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IMP, ISO]
- cell morphogenesis [IMP]
- cellular calcium ion homeostasis [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer morphogenesis [IMP]
- cerebellar granule cell differentiation [IMP]
- cerebellum development [IMP]
- cochlea development [IMP]
- cytosolic calcium ion homeostasis [IMP, ISO]
- detection of mechanical stimulus involved in sensory perception of sound [IMP]
- inner ear development [IMP]
- inner ear morphogenesis [IMP]
- inner ear receptor cell differentiation [IMP]
- lactation [IMP]
- locomotion [IMP]
- locomotory behavior [IMP]
- neuromuscular process controlling balance [IMP]
- neuron differentiation [ISO]
- organelle organization [IMP]
- otolith mineralization [IMP]
- positive regulation of calcium ion transport [IMP]
- regulation of cell size [IMP]
- regulation of synaptic plasticity [IMP]
- sensory perception of sound [IGI, IMP, ISO]
- serotonin metabolic process [IMP]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The in vivo brain interactome of the amyloid precursor protein.
Despite intense research efforts, the physiological function and molecular environment of the amyloid precursor protein has remained enigmatic. Here we describe the application of time-controlled transcardiac perfusion cross-linking, a method for the in vivo mapping of protein interactions in intact tissue, to study the interactome of the amyloid precursor protein (APP). To gain insights into the specificity of reported protein ... [more]
Mol Cell Proteomics Jan. 01, 2008; 7(1);15-34 [Pubmed: 17934213]
Throughput
- Low Throughput
Curated By
- BioGRID