VLDLR
Gene Ontology Biological Process
- cellular response to hypoxia [ISO]
- glycoprotein transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of dendrite development [IGI]
- positive regulation of protein kinase activity [IGI]
- receptor-mediated endocytosis [ISO]
- reelin-mediated signaling pathway [IGI]
- very-low-density lipoprotein particle clearance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RELN
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IMP]
- associative learning [IDA]
- axon guidance [IMP]
- brain development [IMP, ISO]
- cell migration [IMP]
- cell morphogenesis involved in differentiation [IMP]
- central nervous system development [IMP]
- cerebral cortex development [IMP]
- cerebral cortex tangential migration [IMP]
- dendrite development [IGI, IMP]
- dentate gyrus development [ISO]
- forebrain development [IMP]
- glial cell differentiation [IMP]
- hippocampus development [IDA]
- lateral motor column neuron migration [IMP]
- layer formation in cerebral cortex [IMP]
- locomotory behavior [IMP, ISO]
- long-term memory [IDA]
- neuron migration [IGI, IMP, ISO]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of TOR signaling [IDA]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- positive regulation of dendritic spine morphogenesis [IDA, IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP]
- positive regulation of lateral motor column neuron migration [IMP]
- positive regulation of long-term synaptic potentiation [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of small GTPase mediated signal transduction [IDA]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- postsynaptic density assembly [IC]
- postsynaptic density protein 95 clustering [IMP]
- protein localization to synapse [IMP]
- receptor localization to synapse [IMP]
- reelin-mediated signaling pathway [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of behavior [IMP]
- regulation of gene expression [IMP]
- regulation of synaptic transmission [IMP]
- response to pain [IMP]
- spinal cord patterning [IMP]
- thyroid hormone metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin.
Reelin plays critical roles in brain formation by binding to apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor. Several isoforms and fragments of Reelin are generated by alternative splicing and proteolytic cleavage. In addition, two splice variants of ApoER2 have been recognized, namely, LA1237 and LA12378, that differ in the number of ligand-binding type A (LA) repeats. Here, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RELN VLDLR | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| VLDLR RELN | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.828 | BioGRID | 2684906 |
Curated By
- BioGRID