An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-? pathway.

Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S

Evasion of host immunity is a hallmark of cancer; however, mechanisms linking oncogenic mutations and immune escape are incompletely understood. Through loss-of-function screening of 1,001 tumor suppressor genes, we identified death-associated protein kinase 3 (DAPK3) as a previously unrecognized driver of anti-tumor immunity through the stimulator of interferon genes (STING) pathway of cytosolic DNA sensing. Loss of DAPK3 expression or ... [more]

Nat Immunol Dec. 01, 2020; 22(4);485-496 [Pubmed: 33767426]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

DAPK3

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]Rho GTPase binding [IDA]calmodulin-dependent protein kinase activity [IBA]identical protein binding [IPI]leucine zipper domain binding [IPI]protein binding [IPI]protein homodimerization activity [IDA]protein serine/threonine kinase activity [IDA, TAS]

Gene Ontology Cellular Component

LMO7