RNASEL
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [ISO]
- defense response to virus [ISO]
- fat cell differentiation [IGI, IMP]
- negative regulation of viral genome replication [ISO]
- positive regulation of glucose import in response to insulin stimulus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- rRNA processing [ISO]
- regulation of mRNA stability [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLTB
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen.
The interferon-inducible, 2',5'-oligoadenylate (2-5A)-dependent endoribonuclease, RNase L is a unique antiviral RNA-degrading enzyme involved in RNA-metabolism, translational regulation, stress-response besides its anticancer/tumor-suppressor and antibacterial functions. RNase L represents complex cellular RNA-regulations in mammalian cells but diverse functions of RNase L are not completely explained by its 2-5A-regulated endoribonuclease activity. We hypothesized that RNase L has housekeeping function(s) through interaction with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID