BAIT
CTSL
CATL, CTSL1, MEP, RP11-65B23.1
cathepsin L
GO Process (12)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- adaptive immune response [IEP]
- antigen processing and presentation [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cellular response to thyroid hormone stimulus [IEP]
- collagen catabolic process [IDA, TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- innate immune response [TAS]
- macrophage apoptotic process [NAS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDIPT
PIS, PIS1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID