BAIT
BSG
5F7, CD147, EMMPRIN, M6, OK, TCSF, UNQ6505/PRO21383
basigin (Ok blood group)
GO Process (9)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular metabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- protein targeting to plasma membrane [ISS]
- pyruvate metabolic process [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PARK7
DJ-1, DJ1, HEL-S-67p, CTA-215D11.1
parkinson protein 7
GO Process (59)
GO Function (27)
GO Component (9)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of protein kinase B activity [IC]
- cellular response to glyoxal [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA, IMP]
- glycolate biosynthetic process [IDA]
- glyoxal catabolic process [IDA]
- hydrogen peroxide metabolic process [IDA]
- lactate biosynthetic process [IDA]
- methylglyoxal catabolic process to D-lactate [IDA]
- mitochondrion organization [ISS]
- negative regulation of TRAIL-activated apoptotic signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell death [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- negative regulation of death-inducing signaling complex assembly [IC]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of gene expression [IDA]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- negative regulation of hydrogen peroxide-induced neuron death [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of oxidative stress-induced cell death [IDA]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of protein K48-linked deubiquitination [IDA]
- negative regulation of protein acetylation [IDA]
- negative regulation of protein binding [IDA, IGI, IMP]
- negative regulation of protein export from nucleus [IGI]
- negative regulation of protein kinase activity [IGI]
- negative regulation of protein phosphorylation [IGI]
- negative regulation of protein sumoylation [IDA]
- negative regulation of protein ubiquitination [IDA]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- negative regulation of ubiquitin-specific protease activity [IDA]
- positive regulation of L-dopa biosynthetic process [IMP]
- positive regulation of L-dopa decarboxylase activity [IDA]
- positive regulation of androgen receptor activity [IMP]
- positive regulation of dopamine biosynthetic process [IC, IDA]
- positive regulation of gene expression [TAS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of protein kinase B signaling [IC]
- positive regulation of protein localization to nucleus [IDA, IMP]
- positive regulation of pyrroline-5-carboxylate reductase activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, TAS]
- positive regulation of superoxide dismutase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of tyrosine 3-monooxygenase activity [IDA]
- protein stabilization [IDA, IMP]
- regulation of TRAIL receptor biosynthetic process [IMP]
- regulation of androgen receptor signaling pathway [IDA]
- regulation of fibril organization [TAS]
- regulation of inflammatory response [ISS]
- regulation of mitochondrial membrane potential [IMP]
- regulation of neuron apoptotic process [IDA]
Gene Ontology Molecular Function- L-dopa decarboxylase activator activity [IDA]
- androgen receptor binding [IPI]
- core promoter binding [IC]
- cupric ion binding [IDA]
- cuprous ion binding [IDA]
- cytokine binding [IPI]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- glyoxalase (glycolic acid-forming) activity [IDA]
- glyoxalase III activity [IDA]
- identical protein binding [IPI]
- mRNA binding [IDA]
- oxidoreductase activity, acting on peroxide as acceptor [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- repressing transcription factor binding [IPI]
- scaffold protein binding [IPI]
- single-stranded DNA binding [IDA]
- small protein activating enzyme binding [IPI]
- small protein conjugating enzyme binding [IPI]
- superoxide dismutase copper chaperone activity [IDA]
- transcription coactivator activity [IGI, TAS]
- transcription factor binding [IPI]
- tyrosine 3-monooxygenase activator activity [IDA]
- ubiquitin-specific protease binding [IPI]
- L-dopa decarboxylase activator activity [IDA]
- androgen receptor binding [IPI]
- core promoter binding [IC]
- cupric ion binding [IDA]
- cuprous ion binding [IDA]
- cytokine binding [IPI]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- glyoxalase (glycolic acid-forming) activity [IDA]
- glyoxalase III activity [IDA]
- identical protein binding [IPI]
- mRNA binding [IDA]
- oxidoreductase activity, acting on peroxide as acceptor [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- repressing transcription factor binding [IPI]
- scaffold protein binding [IPI]
- single-stranded DNA binding [IDA]
- small protein activating enzyme binding [IPI]
- small protein conjugating enzyme binding [IPI]
- superoxide dismutase copper chaperone activity [IDA]
- transcription coactivator activity [IGI, TAS]
- transcription factor binding [IPI]
- tyrosine 3-monooxygenase activator activity [IDA]
- ubiquitin-specific protease binding [IPI]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 0.98 [Saint Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID