BAIT
TMPRSS2
PP9284, PRSS10
transmembrane protease, serine 2
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STOML2
SLP-2, HSPC108
stomatin (EPB72)-like 2
GO Process (14)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [ISS]
- T cell receptor signaling pathway [IMP]
- cellular calcium ion homeostasis [IMP]
- interleukin-2 production [ISS]
- lipid localization [ISS]
- mitochondrial ATP synthesis coupled proton transport [IMP]
- mitochondrial calcium ion transport [IMP]
- mitochondrial protein processing [ISS]
- mitochondrion organization [IMP]
- positive regulation of cardiolipin metabolic process [IMP]
- positive regulation of mitochondrial DNA replication [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- protein oligomerization [IDA]
- stress-induced mitochondrial fusion [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 0.99 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID