BAIT
TFRC
CD71, T9, TFR, TFR1, TR, TRFR, p90
transferrin receptor
GO Process (6)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
Homo sapiens
PREY
ITPR3
IP3R, IP3R3
inositol 1,4,5-trisphosphate receptor, type 3
GO Process (20)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G-protein coupled receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- calcium ion transport into cytosol [ISS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate-mediated signaling [IDA, ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet activation [TAS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- protein heterooligomerization [ISS]
- protein homooligomerization [ISS]
- regulation of insulin secretion [TAS]
- response to calcium ion [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [ISS]
- brush border [ISS]
- cytoplasm [ISS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [IDA, ISS, TAS]
- integral component of plasma membrane [IDA]
- membrane [IDA]
- myelin sheath [ISS]
- neuronal cell body [ISS]
- nuclear outer membrane [ISS]
- plasma membrane [IDA]
- platelet dense tubular network membrane [TAS]
- receptor complex [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 0.98 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID