BAIT
CTSL
CATL, CTSL1, MEP, RP11-65B23.1
cathepsin L
GO Process (12)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- adaptive immune response [IEP]
- antigen processing and presentation [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cellular response to thyroid hormone stimulus [IEP]
- collagen catabolic process [IDA, TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- innate immune response [TAS]
- macrophage apoptotic process [NAS]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDIA3
ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC
protein disulfide isomerase family A, member 3
GO Process (12)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [IBA, TAS]
- protein import into nucleus [TAS]
- protein retention in ER lumen [TAS]
- proteolysis [TAS]
- response to endoplasmic reticulum stress [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID