BAIT
FURIN
FUR, PACE, PCSK3, SPC1
furin (paired basic amino acid cleaving enzyme)
GO Process (29)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cell proliferation [IMP]
- cellular protein metabolic process [TAS]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- negative regulation of nerve growth factor production [IDA]
- negative regulation of transforming growth factor beta1 production [IMP]
- nerve growth factor processing [TAS]
- nerve growth factor production [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptide biosynthetic process [IDA]
- peptide hormone processing [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- positive regulation of membrane protein ectodomain proteolysis [IC]
- post-translational protein modification [TAS]
- protein processing [IDA, IMP]
- proteolysis [TAS]
- regulation of endopeptidase activity [IDA]
- regulation of protein catabolic process [IMP]
- secretion by cell [IDA]
- signal peptide processing [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [IEP]
- viral process [TAS]
- viral protein processing [TAS]
- virion assembly [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TPM1
C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
tropomyosin 1 (alpha)
GO Process (17)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular component movement [TAS]
- cellular response to reactive oxygen species [IEP]
- cytoskeleton organization [TAS]
- muscle contraction [TAS]
- muscle filament sliding [ISS, TAS]
- negative regulation of cell migration [ISS]
- positive regulation of ATPase activity [ISS]
- positive regulation of cell adhesion [ISS]
- positive regulation of heart rate by epinephrine [ISS]
- positive regulation of stress fiber assembly [ISS]
- regulation of heart contraction [TAS]
- regulation of muscle contraction [TAS]
- ruffle organization [ISS]
- sarcomere organization [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID