BAIT
DPP4
ADABP, ADCP2, CD26, DPPIV, TP103
dipeptidyl-peptidase 4
GO Process (7)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SNX3
Grd19, MCOPS8, SDP3, RP3-429G5.4
sorting nexin 3
GO Process (12)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- intralumenal vesicle formation [IMP]
- membrane invagination [IDA]
- negative regulation of early endosome to late endosome transport [IDA]
- negative regulation of phagocytosis [IMP]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein transport [IDA]
- negative regulation of viral entry into host cell [IDA]
- positive regulation of neuron projection development [ISS]
- protein to membrane docking [IDA]
- regulation of Wnt signaling pathway [IMP]
- response to bacterium [IDA]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 0.99 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID