BAIT
TMPRSS4
CAPH2, MT-SP2, TMPRSS3, UNQ776/PRO1570
transmembrane protease, serine 4
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANO6
BDPLT7, SCTS, TMEM16F
anoctamin 6
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- activation of blood coagulation via clotting cascade [IMP]
- blood coagulation [ISS]
- cation transmembrane transport [IDA, ISS]
- cation transport [IDA]
- chloride transmembrane transport [IMP]
- chloride transport [IMP]
- ion transmembrane transport [TAS]
- phosphatidylserine exposure on blood platelet [IMP]
- phospholipid scrambling [ISS]
- positive regulation of endothelial cell apoptotic process [IMP]
- regulation of anion transport [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
SARS-CoV-2-host proteome interactions for antiviral drug discovery.
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins that functionally associate with SARS-CoV-2 are localized in the corresponding subnetwork within the comprehensive human interactome. Therefore, constructing a downstream ... [more]
Mol Syst Biol Dec. 01, 2020; 17(11);e10396 [Pubmed: 34709727]
Quantitative Score
- 1.0 [Saint Score]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence interactions are assigned based on their statistical filtering score (BFDR =< 0.01) and further refined using the CRAPome contaminant repository.
- The associated score is the original published SAINT score determined by the authors using Significance Analysis of INTeractome (SAINT) express version 3.6.0.
Curated By
- BioGRID