BAIT

ED

1X5, CG12676, CG15424, CG16842, CT13476, CT35484, Dmel\CG12676, E(Elp)24D, E(Elp)[24D], l(2)k01102, Dmel_CG12676

echinoid

GO Process (24)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

branch fusion, open tracheal system [IMP]

contractile actin filament bundle assembly [IMP]

dorsal appendage formation [IMP]

dorsal closure [IMP]

epidermal growth factor receptor signaling pathway [IMP, IPI]

homophilic cell adhesion via plasma membrane adhesion molecules [IDA, IMP]

imaginal disc-derived wing morphogenesis [IMP]

inter-male aggressive behavior [IMP]

lateral inhibition [IMP]

morphogenesis of an epithelium [IMP]

muscle organ morphogenesis [IMP]

mushroom body development [IMP]

negative regulation of epidermal growth factor receptor signaling pathway [IGI, IMP, NAS]

negative regulation of fusion cell fate specification [IMP]

negative regulation of hippo signaling [IGI]

negative regulation of neurogenesis [IMP]

negative regulation of organ growth [IMP]

regulation of actin cytoskeleton organization [IMP]

regulation of actin cytoskeleton organization by cell-cell adhesion [IMP]

regulation of cell shape [IMP]

regulation of hippo signaling [IPI]

sensory organ development [IMP]

single organismal cell-cell adhesion [IMP]

wound healing [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

adherens junction [IDA]

cell-cell adherens junction [IDA]

integral component of membrane [ISM]

plasma membrane [IDA]

CRISPR Database FlyBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Drosophila melanogaster

PREY

DCX-EMAP

CG13466, CG13467, CG42247, Dmel\CG42247, Dmel_CG13466, Dmel_CG13467, anon-71Aa, dmEMAP, Dmel_CG42247

Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog

GO Process (4)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

adult locomotory behavior [IMP]

melanotic encapsulation of foreign target [IMP]

microtubule-based process [NAS]

sensory perception of sound [IMP]

Gene Ontology Molecular Function

microtubule binding [IDA, ISS, NAS]

Gene Ontology Cellular Component

sensory dendrite [IDA]

CRISPR Database FlyBase Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Drosophila melanogaster

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A protein interaction map of Drosophila melanogaster.

Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, Vijayadamodar G, Pochart P, Machineni H, Welsh M, Kong Y, Zerhusen B, Malcolm R, Varrone Z, Collis A, Minto M, Burgess S, McDaniel L, Stimpson E, Spriggs F, Williams J, Neurath K, Ioime N, Agee M, Voss E, Furtak K, Renzulli R, Aanensen N, Carrolla S, Bickelhaupt E, Lazovatsky Y, DaSilva A, Zhong J, Stanyon CA, Finley RL, White KP, Braverman M, Jarvie T, Gold S, Leach M, Knight J, Shimkets RA, McKenna MP, Chant J, Rothberg JM

Drosophila melanogaster is a proven model system for many aspects of human biology. Here we present a two-hybrid-based protein-interaction map of the fly proteome. A total of 10,623 predicted transcripts were isolated and screened against standard and normalized complementary DNA libraries to produce a draft map of 7048 proteins and 20,405 interactions. A computational method of rating two-hybrid interaction confidence ... [more]

Science Dec. 05, 2003; 302(5651);1727-36 [Pubmed: 14605208]

Throughput

High Throughput

Curated By

BioGRID