BAIT
FGD5
ZFYVE23
FYVE, RhoGEF and PH domain containing 5
GO Process (6)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ENO1
ENO1L1, MPB1, NNE, PPH
enolase 1, (alpha)
GO Process (9)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- glycolytic process [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- response to virus [IEP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.
Most basal-like breast cancers (BLBCs) are triple-negative breast cancers (TNBCs), which have the worst prognosis and distant metastasis-free survival among breast cancer subtypes. Now, no targeted therapies are available for patients with BLBC due to the lack of reliable and effective molecular targets. Here, we performed the BLBC tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance ... [more]
Sci Transl Med Dec. 24, 2020; 13(586); [Pubmed: 33762435]
Quantitative Score
- 1548.87 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture-MS was carried out to identify high-confidence protein interactions.
Curated By
- BioGRID