BAIT

FGD5

ZFYVE23
FYVE, RhoGEF and PH domain containing 5
Glioblastoma Project
Homo sapiens
PREY

HADHA

ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

Li K, Zhang TT, Zhao CX, Wang F, Cui B, Yang ZN, Lv XX, Yeerjiang Z, Yuan YF, Yu JM, Wang ZH, Zhang XW, Yu JJ, Liu SS, Shang S, Huang B, Hua F, Hu ZW

Most basal-like breast cancers (BLBCs) are triple-negative breast cancers (TNBCs), which have the worst prognosis and distant metastasis-free survival among breast cancer subtypes. Now, no targeted therapies are available for patients with BLBC due to the lack of reliable and effective molecular targets. Here, we performed the BLBC tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance ... [more]

Sci Transl Med Dec. 24, 2020; 13(586); [Pubmed: 33762435]

Quantitative Score

  • 658.08 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • Affinity capture-MS was carried out to identify high-confidence protein interactions.

Curated By

  • BioGRID