ADAR
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, ISO]
- base conversion or substitution editing [ISO]
- defense response to virus [IMP]
- definitive hemopoiesis [IMP]
- erythrocyte differentiation [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell homeostasis [IMP]
- in utero embryonic development [IMP]
- miRNA loading onto RISC involved in gene silencing by miRNA [ISO]
- negative regulation of RNA interference [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IMP, ISO]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of viral genome replication [IMP]
- osteoblast differentiation [IMP]
- positive regulation of viral genome replication [IMP, ISO]
- pre-miRNA processing [ISO]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- protein export from nucleus [ISO]
- protein import into nucleus [ISO]
- response to interferon-alpha [ISO]
- response to virus [ISO]
- somatic diversification of immune receptors via somatic mutation [IDA]
Gene Ontology Molecular Function
EIF2AK2
Gene Ontology Biological Process
- activation of MAPKK activity [IMP]
- evasion or tolerance by virus of host immune response [TAS]
- modulation by virus of host morphology or physiology [TAS]
- modulation by virus of host process [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of translation [IDA, IMP]
- negative regulation of viral genome replication [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of NIK/NF-kappaB signaling [ISS]
- positive regulation of chemokine production [ISS]
- positive regulation of cytokine production [ISS]
- positive regulation of stress-activated MAPK cascade [ISS]
- protein autophosphorylation [IDA, IMP]
- protein phosphorylation [IDA]
- regulation of NLRP3 inflammasome complex assembly [ISS]
- regulation of hematopoietic progenitor cell differentiation [ISS]
- regulation of hematopoietic stem cell differentiation [ISS]
- regulation of hematopoietic stem cell proliferation [ISS]
- response to interferon-alpha [IDA]
- response to virus [IMP]
- viral life cycle [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
The RNA-editing enzyme ADAR1 is a double-stranded RNA (dsRNA) binding protein that modifies cellular and viral RNA sequences by adenosine deamination. ADAR1 has been demonstrated to play important roles in embryonic erythropoiesis, viral response, and RNA interference. In human hepatitis virus infection, ADAR1 has been shown to target viral RNA and to suppress viral replication through dsRNA editing. It is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID