ADAR
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, ISO]
- base conversion or substitution editing [ISO]
- defense response to virus [IMP]
- definitive hemopoiesis [IMP]
- erythrocyte differentiation [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell homeostasis [IMP]
- in utero embryonic development [IMP]
- miRNA loading onto RISC involved in gene silencing by miRNA [ISO]
- negative regulation of RNA interference [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IMP, ISO]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of viral genome replication [IMP]
- osteoblast differentiation [IMP]
- positive regulation of viral genome replication [IMP, ISO]
- pre-miRNA processing [ISO]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- protein export from nucleus [ISO]
- protein import into nucleus [ISO]
- response to interferon-alpha [ISO]
- response to virus [ISO]
- somatic diversification of immune receptors via somatic mutation [IDA]
Gene Ontology Molecular Function
ILF3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
The RNA-editing enzyme ADAR1 is a double-stranded RNA (dsRNA) binding protein that modifies cellular and viral RNA sequences by adenosine deamination. ADAR1 has been demonstrated to play important roles in embryonic erythropoiesis, viral response, and RNA interference. In human hepatitis virus infection, ADAR1 has been shown to target viral RNA and to suppress viral replication through dsRNA editing. It is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID