CBL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ABL1
Gene Ontology Biological Process
- B cell proliferation [IMP]
- B cell proliferation involved in immune response [IGI, IMP]
- B cell receptor signaling pathway [IMP]
- B-1 B cell homeostasis [IMP]
- Bergmann glial cell differentiation [IGI]
- DNA damage induced protein phosphorylation [ISO]
- actin cytoskeleton organization [IDA]
- actin filament branching [IMP]
- activated T cell proliferation [IMP]
- alpha-beta T cell differentiation [IGI]
- cell migration [IBA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to lipopolysaccharide [IMP]
- cerebellum morphogenesis [IGI]
- collateral sprouting [IMP]
- epidermal growth factor receptor signaling pathway [IGI]
- innate immune response [IBA]
- microspike assembly [IDA]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of cell-cell adhesion [IGI]
- negative regulation of cellular senescence [IGI]
- negative regulation of endothelial cell apoptotic process [IGI]
- negative regulation of mitotic cell cycle [IDA, IGI]
- negative regulation of phospholipase C activity [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- neuromuscular process controlling balance [IGI]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IGI, ISO]
- phagocytosis [IGI, IMP]
- platelet-derived growth factor receptor signaling pathway [IDA, IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IGI]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of interferon-gamma secretion [IGI]
- positive regulation of interleukin-2 secretion [IGI]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of neuron death [IMP]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of oxidoreductase activity [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [IGI]
- regulation of actin cytoskeleton organization [IGI]
- regulation of cell cycle [IDA]
- regulation of cellular senescence [IGI]
- regulation of extracellular matrix organization [IGI]
- regulation of response to DNA damage stimulus [ISO]
- response to oxidative stress [IMP, ISO]
- signal transduction in response to DNA damage [IBA, ISO]
- spleen development [IMP]
- substrate adhesion-dependent cell spreading [IDA]
- thymus development [IMP]
- transitional one stage B cell differentiation [IMP]
Gene Ontology Molecular Function- ATP binding [IDA, ISO]
- SH3 domain binding [ISO]
- actin filament binding [IDA]
- delta-catenin binding [ISO]
- kinase activity [IDA]
- magnesium ion binding [IDA, ISO]
- manganese ion binding [IDA, ISO]
- mitogen-activated protein kinase binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IGI, IMP, ISO]
- receptor binding [IBA]
- syntaxin binding [ISO]
- ATP binding [IDA, ISO]
- SH3 domain binding [ISO]
- actin filament binding [IDA]
- delta-catenin binding [ISO]
- kinase activity [IDA]
- magnesium ion binding [IDA, ISO]
- manganese ion binding [IDA, ISO]
- mitogen-activated protein kinase binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- proline-rich region binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA, IGI, IMP, ISO]
- receptor binding [IBA]
- syntaxin binding [ISO]
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- cell leading edge [IDA]
- cytoplasm [IDA, ISO]
- cytosol [ISA, ISO]
- endoplasmic reticulum [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- growth cone [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- ruffle [ISO]
- synapse [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-?B activation.
Intestinal fungi are critical for modulating host immune homeostasis and underlying mechanisms remain unclear. We show that dendritic cell (DC)-specific deficiency of casitas B-lineage lymphoma (c-Cbl) renders mice susceptible to dextran sodium sulfate (DSS)-induced colitis. Mechanistically, we identify that c-Cbl functions downstream of Dectin-2 and Dectin-3 to mediate the ubiquitination and degradation of noncanonical nuclear factor ?B subunit RelB. Thus, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CBL ABL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ABL1 CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ABL1 CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| ABL1 CBL | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 692104 | |
| ABL1 CBL | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 734419 |
Curated By
- BioGRID