PREY

NFKBIA

IKBA, MAD-3, NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
GO Process (31)
GO Function (7)
GO Component (5)

Gene Ontology Biological Process

Homo sapiens

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex.

Siu KL, Kok KH, Ng MJ, Poon VKM, Yuen KY, Zheng BJ, Jin DY

Severe acute respiratory syndrome (SARS) coronavirus is highly pathogenic in humans and evades innate immunity at multiple levels. It has evolved various strategies to counteract the production and action of type I interferons, which mobilize the front-line defense against viral infection. In this study we demonstrate that SARS coronavirus M protein inhibits gene transcription of type I interferons. M protein ... [more]

J Biol Chem Jun. 12, 2009; 284(24);16202-16209 [Pubmed: 19380580]

Throughput

  • Low Throughput

Additional Notes

  • TBK1 IKBKE kinase complex

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
TBK1 NFKBIA
Biochemical Activity
Biochemical Activity

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Low-BioGRID
724047

Curated By

  • BioGRID