CENPF
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [NAS]
- chromosome segregation [IMP, NAS]
- kinetochore assembly [NAS]
- metaphase plate congression [IDA]
- mitotic cell cycle [IMP, TAS]
- mitotic spindle assembly checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- protein transport [IDA, IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell cycle [TAS]
- regulation of striated muscle tissue development [ISS]
- response to drug [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KPNA1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of virus [TAS]
- positive regulation of protein import into nucleus [ISS]
- regulation of DNA recombination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.
Centromere protein F (CENP-F) is a component of the kinetochore and a regulator of cell cycle progression. CENP-F recruits the dynein transport machinery and orchestrates several cell cycle-specific transport events, including transport of the nucleus, mitochondria and chromosomes. A key regulatory step for several of these functions is likely the G2 phase-specific export of CENP-F from the nucleus to the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID