BAIT
CENPF
CENF, PRO1779, hcp-1, RP11-262H5.1
centromere protein F, 350/400kDa
GO Process (13)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [NAS]
- chromosome segregation [IMP, NAS]
- kinetochore assembly [NAS]
- metaphase plate congression [IDA]
- mitotic cell cycle [IMP, TAS]
- mitotic spindle assembly checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- protein transport [IDA, IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell cycle [TAS]
- regulation of striated muscle tissue development [ISS]
- response to drug [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KPNA1
IPOA5, NPI-1, RCH2, SRP1
karyopherin alpha 1 (importin alpha 5)
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of virus [TAS]
- positive regulation of protein import into nucleus [ISS]
- regulation of DNA recombination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F.
Centromere protein F (CENP-F) is a component of the kinetochore and a regulator of cell cycle progression. CENP-F recruits the dynein transport machinery and orchestrates several cell cycle-specific transport events, including transport of the nucleus, mitochondria and chromosomes. A key regulatory step for several of these functions is likely the G2 phase-specific export of CENP-F from the nucleus to the ... [more]
Cell Cycle Aug. 03, 2017; 16(15);1414-1429 [Pubmed: 28723232]
Throughput
- Low Throughput
Curated By
- BioGRID