BAIT

EDEM3

2310050N11Rik
ER degradation enhancer, mannosidase alpha-like 3
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

SEL1L

PRO1063, SEL1-LIKE, SEL1L1, UNQ128/PRO1063
sel-1 suppressor of lin-12-like (C. elegans)
UPS Project
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning.

Manica G, Ghenea S, Munteanu CVA, Martin EC, Butnaru C, Surleac M, Chiritoiu GN, Alexandru PR, Petrescu AJ, Petrescu SM

EDEM3 recognizes and directs misfolded proteins to the ER-associated protein degradation (ERAD) process. EDEM3 was predicted to act as lectin or as a mannosidase because of its homology with the GH47 catalytic domain of the Man1B1, but the contribution of the other regions remained unresolved. Here, we dissect the molecular determinants governing EDEM3 function and its cellular interactions. LC/MS analysis ... [more]

Int J Mol Sci Feb. 22, 2021; 22(4); [Pubmed: 33671632]

Throughput

  • High Throughput

Curated By

  • BioGRID