BAIT
ST3GAL4
CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
GO Process (11)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- O-glycan processing [TAS]
- carbohydrate metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cognition [IMP]
- glycosaminoglycan metabolic process [TAS]
- keratan sulfate biosynthetic process [TAS]
- keratan sulfate metabolic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- sialylation [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
HLA-E
EA1.2, EA2.1, HLA-6.2, MHC, QA1, DAMA-277I14.1
major histocompatibility complex, class I, E
GO Process (12)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib [IDA]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of natural killer cell mediated immunity [IDA]
- protection from natural killer cell mediated cytotoxicity [IDA]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.508031429 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.508031429200925, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Curated By
- BioGRID