BAIT

PSMG2

CLAST3, HCCA3, HsT1707, MDS003, PAC2, TNFSF5IP1

proteasome (prosome, macropain) assembly chaperone 2

GO Process (1)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

proteasome assembly [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

nucleus [IDA, ISS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PSMB6

DELTA, LMPY, Y

proteasome (prosome, macropain) subunit, beta type, 6

GO Process (21)

GO Function (1)

GO Component (8)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]

G1/S transition of mitotic cell cycle [TAS]

RNA metabolic process [TAS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]

antigen processing and presentation of peptide antigen via MHC class I [TAS]

apoptotic process [TAS]

cellular nitrogen compound metabolic process [TAS]

gene expression [TAS]

mRNA metabolic process [TAS]

mitotic cell cycle [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

protein polyubiquitination [TAS]

regulation of apoptotic process [TAS]

regulation of cellular amino acid metabolic process [TAS]

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

small molecule metabolic process [TAS]

viral process [TAS]

Gene Ontology Molecular Function

endopeptidase activity [NAS]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

nucleoplasm [IDA, TAS]

proteasome complex [IDA]

proteasome core complex [ISS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)

Huttlin EL, Pontano-Vaites L, Navarrete-Perea J, Bruckner RJ, Gebreab F, Gygi MP, Thornock A, Fu S, Maenpaa E, Golbazi A, Stricker K, Guha Thakurta S, Zhang T, Rad R, Paulo JA, Harper JW, Gygi SP

As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]

Status: Pre-Publication Dataset

Quantitative Score

0.62731165 [compPASS Score]

Throughput

High Throughput

Additional Notes

BioPlex HCT (unpublished interaction)
BioPlex HCT HCT116 cells CompPASS score = 0.62731164999205, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PSMB6 PSMG2	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Wan C (2015)	High	0.983	BioGRID	1268326

Curated By

BioGRID