KCNE1
Gene Ontology Biological Process
- cardiac muscle cell action potential involved in contraction [IMP]
- cellular response to cAMP [IDA]
- membrane repolarization [IDA]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IDA, IMP]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion transmembrane transport [IDA]
- protein N-linked glycosylation [IDA]
- protein O-linked glycosylation [IDA]
- regulation of delayed rectifier potassium channel activity [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of potassium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- sensory perception of sound [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- telethonin binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- delayed rectifier potassium channel activity [IDA]
- potassium channel regulator activity [IDA]
- protein binding [IPI]
- telethonin binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
SFXN3
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.865053778 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.865053777777438, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNE1 SFXN3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9975 | BioGRID | 3112473 |
Curated By
- BioGRID