ADAM33
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRP6
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IMP]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- Wnt signaling pathway involved in somitogenesis [IBA]
- anterior/posterior pattern specification [IBA]
- axis elongation involved in somitogenesis [IBA]
- bone morphogenesis [IBA]
- bone remodeling [IBA]
- branching involved in mammary gland duct morphogenesis [IBA]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural crest cell differentiation [IC]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IC]
- cellular response to cholesterol [IMP]
- cerebellum morphogenesis [IBA]
- cerebral cortex development [IBA]
- convergent extension [IBA]
- embryonic camera-type eye morphogenesis [IBA]
- embryonic limb morphogenesis [IBA]
- embryonic pattern specification [IBA]
- embryonic retina morphogenesis in camera-type eye [IBA]
- external genitalia morphogenesis [IBA]
- face morphogenesis [IBA]
- gastrulation with mouth forming second [IBA]
- midbrain development [IBA]
- midbrain-hindbrain boundary development [IBA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- negative regulation of smooth muscle cell apoptotic process [IMP]
- neural crest cell differentiation [IDA]
- neural crest formation [IDA]
- neural tube closure [IBA]
- odontogenesis of dentin-containing tooth [IBA]
- palate development [IBA]
- pericardium morphogenesis [IBA]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- primitive streak formation [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IBA]
- regulation of fat cell differentiation [IBA]
- regulation of ossification [IBA]
- synaptic transmission [IBA]
- thalamus development [IBA]
- toxin transport [IMP]
- trachea cartilage morphogenesis [IBA]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI]
- apolipoprotein binding [IBA]
- coreceptor activity involved in Wnt signaling pathway [IDA]
- frizzled binding [IPI]
- identical protein binding [IPI]
- kinase inhibitor activity [IMP]
- low-density lipoprotein receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- receptor binding [IPI]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.725141399 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.725141398648404, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADAM33 LRP6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8928 | BioGRID | 2259716 | |
| ADAM33 LRP6 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8191 | BioGRID | 3102023 |
Curated By
- BioGRID