BAIT
PDGFB
IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, LL22NC03-10C3.2
platelet-derived growth factor beta polypeptide
GO Process (60)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to mycophenolic acid [ISS]
- embryonic placenta development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- hemopoiesis [IMP]
- innate immune response [TAS]
- metanephric glomerular mesangial cell development [ISS]
- monocyte chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- paracrine signaling [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive chemotaxis [IDA]
- positive regulation of DNA biosynthetic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of glomerular mesangial cell proliferation [IDA]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of metanephric mesenchymal cell migration [IDA]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- reactive oxygen species metabolic process [IMP]
- response to wounding [IDA, NAS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
MYCBP2
PAM, AC001226.5
MYC binding protein 2, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.645176573 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.645176573473107, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDGFB MYCBP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9094 | BioGRID | 2257744 | |
| PDGFB MYCBP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.904 | BioGRID | 3116259 |
Curated By
- BioGRID