YWHAG
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [NAS]
- negative regulation of protein serine/threonine kinase activity [NAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of neuron differentiation [IMP]
- regulation of signal transduction [NAS]
- regulation of synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DMTN
Gene Ontology Biological Process
- actin cytoskeleton organization [ISS]
- actin filament bundle assembly [IDA, TAS]
- actin filament reorganization [ISS]
- calcium-mediated signaling using extracellular calcium source [ISS]
- calcium-mediated signaling using intracellular calcium source [ISS]
- cellular response to cAMP [IDA]
- cellular response to calcium ion [ISS]
- cytoskeleton organization [TAS]
- erythrocyte development [ISS]
- negative regulation of cell-substrate adhesion [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of peptidyl-threonine phosphorylation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of protein targeting to membrane [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of blood coagulation [ISS]
- positive regulation of fibroblast migration [ISS]
- positive regulation of integrin-mediated signaling pathway [ISS]
- positive regulation of platelet aggregation [ISS]
- positive regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of wound healing [ISS]
- protein complex assembly [IDA, ISS]
- protein secretion by platelet [ISS]
- regulation of actin cytoskeleton organization [IDA]
- regulation of cell shape [IMP]
- regulation of filopodium assembly [IMP]
- regulation of lamellipodium assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999021 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999021291845, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DMTN YWHAG | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9363 | BioGRID | 2254079 | |
| DMTN YWHAG | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9137 | BioGRID | 3080134 | |
| YWHAG DMTN | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3532137 | |
| YWHAG DMTN | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3536177 |
Curated By
- BioGRID