FLCN
Gene Ontology Biological Process
- TOR signaling [IMP]
- cell-cell junction assembly [ISS]
- hemopoiesis [ISS]
- in utero embryonic development [ISS]
- negative regulation of ATP biosynthetic process [ISS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of TOR signaling [ISS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation involved in kidney development [ISS]
- negative regulation of energy homeostasis [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of mitochondrion organization [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein localization to nucleus [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of TOR signaling [ISS]
- positive regulation of apoptotic process [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, ISS]
- regulation of TOR signaling [ISS]
- regulation of cytokinesis [IMP]
- regulation of histone acetylation [ISS]
- regulation of pro-B cell differentiation [ISS]
- regulation of protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YWHAH
Gene Ontology Biological Process
- apoptotic process [TAS]
- glucocorticoid catabolic process [IDA]
- glucocorticoid receptor signaling pathway [IDA]
- intracellular protein transport [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane depolarization during action potential [IDA]
- membrane organization [TAS]
- negative regulation of dendrite morphogenesis [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of neuron differentiation [ISS]
- regulation of sodium ion transmembrane transporter activity [IDA]
- regulation of sodium ion transport [IDA]
- regulation of synaptic plasticity [ISS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.988070355 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.98807035539289, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FLCN YWHAH | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9966 | BioGRID | 3143910 |
Curated By
- BioGRID