BAIT
C5AR1
C5A, C5AR, C5R1, CD88
complement component 5a receptor 1
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPK activity [TAS]
- activation of phospholipase C activity [TAS]
- cellular defense response [TAS]
- chemotaxis [TAS]
- complement component C5a signaling pathway [IDA]
- immune response [TAS]
- mRNA transcription from RNA polymerase II promoter [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- sensory perception of chemical stimulus [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDS2
RP4-680N4.2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.39355536 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.393555359928628, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Curated By
- BioGRID