FBXO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL6ST
Gene Ontology Biological Process
- ciliary neurotrophic factor-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- interleukin-27-mediated signaling pathway [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- leukemia inhibitory factor signaling pathway [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-6-mediated signaling pathway [IDA]
- oncostatin-M-mediated signaling pathway [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of acute inflammatory response [IC]
- positive regulation of adaptive immune response [IC]
- positive regulation of cardiac muscle hypertrophy [TAS]
- positive regulation of cell proliferation [IDA, IGI]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation vascular endothelial growth factor production [TAS]
- response to cytokine [IDA]
Gene Ontology Molecular Function- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
- ciliary neurotrophic factor receptor activity [IDA]
- ciliary neurotrophic factor receptor binding [IPI]
- growth factor binding [IPI]
- interleukin-27 receptor activity [IC]
- interleukin-6 binding [IPI]
- interleukin-6 receptor activity [IDA]
- interleukin-6 receptor binding [IPI]
- leukemia inhibitory factor receptor activity [IDA]
- oncostatin-M receptor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.921103042 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.921103042177963, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FBXO2 IL6ST | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3119232 | |
| FBXO2 IL6ST | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| FBXO2 IL6ST | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID