HLA-A
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent [IDA]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytokine-mediated signaling pathway [TAS]
- detection of bacterium [IMP]
- immune response [IMP, NAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of T cell mediated cytotoxicity [IDA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of memory T cell activation [IDA]
- protection from natural killer cell mediated cytotoxicity [IDA]
- regulation of defense response to virus by virus [TAS]
- regulation of immune response [TAS]
- type I interferon signaling pathway [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi apparatus [IDA, ISS]
- Golgi medial cisterna [IDA]
- Golgi membrane [TAS]
- MHC class I protein complex [IDA, ISS]
- cell surface [IDA, ISS]
- early endosome membrane [TAS]
- endoplasmic reticulum [IDA, ISS]
- endoplasmic reticulum exit site [IDA]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of plasma membrane [NAS]
- membrane [IDA]
- phagocytic vesicle membrane [TAS]
- plasma membrane [TAS]
ITFG1
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.966759322 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.96675932172041, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ITFG1 HLA-A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID