INHA
Gene Ontology Biological Process
- SMAD protein signal transduction [IBA]
- cell cycle arrest [TAS]
- cell development [IBA]
- cell differentiation [TAS]
- cell surface receptor signaling pathway [TAS]
- cell-cell signaling [TAS]
- erythrocyte differentiation [NAS]
- hemoglobin biosynthetic process [IDA]
- negative regulation of B cell differentiation [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of follicle-stimulating hormone secretion [NAS]
- negative regulation of interferon-gamma biosynthetic process [TAS]
- negative regulation of macrophage differentiation [TAS]
- negative regulation of phosphorylation [TAS]
- nervous system development [NAS]
- ovarian follicle development [NAS]
- positive regulation of follicle-stimulating hormone secretion [TAS]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- regulation of cell cycle [IDA]
- regulation of cell proliferation [IDA]
- response to external stimulus [TAS]
- signal transduction [TAS]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PDIA3
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [IBA, TAS]
- protein import into nucleus [TAS]
- protein retention in ER lumen [TAS]
- proteolysis [TAS]
- response to endoplasmic reticulum stress [IBA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.546124181 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.546124180945156, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
INHA PDIA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9891 | BioGRID | 1175363 | |
INHA PDIA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9979 | BioGRID | 2234644 | |
INHA PDIA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9985 | BioGRID | 3071439 |
Curated By
- BioGRID