DEFA6
Gene Ontology Biological Process
Gene Ontology Cellular Component
ZFPM1
Gene Ontology Biological Process
- T-helper cell lineage commitment [IC]
- atrial septum morphogenesis [ISS]
- atrioventricular valve morphogenesis [ISS]
- blood coagulation [TAS]
- cardiac muscle tissue morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- erythrocyte differentiation [ISS]
- heart development [IBA]
- megakaryocyte differentiation [IBA, ISS]
- mitral valve formation [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of interleukin-4 biosynthetic process [IDA]
- negative regulation of mast cell differentiation [ISS]
- negative regulation of protein binding [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- outflow tract morphogenesis [ISS]
- platelet formation [IGI]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- regulation of definitive erythrocyte differentiation [IDA, IMP]
- transcriptional activation by promoter-enhancer looping [ISS]
- tricuspid valve formation [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999998 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999998418408, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DEFA6 ZFPM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2218584 | |
| DEFA6 ZFPM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3058046 |
Curated By
- BioGRID