CHRNA4
Gene Ontology Biological Process
- B cell activation [ISS]
- DNA repair [IMP]
- action potential [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- membrane depolarization [ISS]
- neurological system process [IMP]
- regulation of dopamine secretion [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- synaptic transmission [NAS, TAS]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WLS
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.376013158 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.376013157543002, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA4 WLS | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9961 | BioGRID | 3104094 |
Curated By
- BioGRID