BAIT
CCL3
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
chemokine (C-C motif) ligand 3
GO Process (52)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [IEP, IMP]
- T cell chemotaxis [IDA]
- astrocyte cell migration [ISS]
- behavior [IDA]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell activation [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemotaxis [IDA]
- cytoskeleton organization [IDA]
- eosinophil chemotaxis [IDA]
- eosinophil degranulation [IDA]
- exocytosis [IDA]
- granulocyte chemotaxis [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymphocyte chemotaxis [IDA]
- macrophage chemotaxis [ISS]
- monocyte chemotaxis [IC, IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of bone mineralization [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of osteoclast differentiation [IDA]
- neutrophil chemotaxis [IDA]
- osteoblast differentiation [IEP]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein kinase B signaling [IEP]
- positive regulation of tumor necrosis factor production [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of sensory perception of pain [IDA]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IDA]
- response to toxic substance [IDA]
- signaling [IEP]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
TNIK
TRAF2 and NCK interacting kinase
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.999999793 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999793314751, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCL3 TNIK | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3064177 |
Curated By
- BioGRID