RGCC
Gene Ontology Biological Process
- cellular response to hypoxia [IMP]
- complement activation [IMP]
- fibroblast activation [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-cell adhesion mediated by cadherin [IDA]
- negative regulation of cytokine secretion [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of exit from mitosis [IDA]
- negative regulation of fibroblast growth factor production [IDA]
- negative regulation of mitotic cell cycle phase transition [IDA]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of cytokine secretion [IMP]
- positive regulation of endothelial cell apoptotic process [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA, IMP]
- positive regulation of extracellular matrix constituent secretion [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of mitosis [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of stress fiber assembly [IDA]
Gene Ontology Molecular Function
TLN1
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell-cell junction assembly [TAS]
- cellular component movement [NAS]
- cellular protein metabolic process [TAS]
- cytoskeletal anchoring at plasma membrane [NAS]
- endoplasmic reticulum unfolded protein response [TAS]
- muscle contraction [TAS]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.946990069 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.946990069449578, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9995 | BioGRID | 1197349 | |
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9926 | BioGRID | 2239747 | |
| RGCC TLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9937 | BioGRID | 3115216 |
Curated By
- BioGRID