BAIT
C15ORF59
chromosome 15 open reading frame 59
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
PKD2
APKD2, PC2, PKD4, Pc-2, TRPP2
polycystic kidney disease 2 (autosomal dominant)
GO Process (48)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- aorta development [IEP]
- branching involved in ureteric bud morphogenesis [IEP]
- calcium ion transmembrane transport [IDA]
- calcium ion transport [IDA, ISS]
- cell cycle arrest [ISS]
- cellular response to fluid shear stress [IMP]
- cellular response to hydrostatic pressure [IDA]
- cellular response to osmotic stress [IDA]
- cellular response to reactive oxygen species [NAS]
- centrosome duplication [NAS]
- cytoplasmic sequestering of transcription factor [IMP]
- detection of mechanical stimulus [IBA, ISS]
- detection of nodal flow [ISS]
- determination of left/right symmetry [ISS]
- determination of liver left/right asymmetry [IMP]
- embryonic placenta development [ISS]
- heart development [IEP]
- heart looping [IMP]
- liver development [IEP]
- mesonephric duct development [IEP]
- mesonephric tubule development [IEP]
- metanephric S-shaped body morphogenesis [IEP]
- metanephric ascending thin limb development [IEP]
- metanephric cortex development [IEP]
- metanephric cortical collecting duct development [IEP]
- metanephric distal tubule development [IEP]
- metanephric mesenchyme development [IEP]
- metanephric part of ureteric bud development [IEP]
- metanephric smooth muscle tissue development [IEP]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of cell proliferation [NAS]
- negative regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- neural tube development [IEP]
- placenta blood vessel development [ISS]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IDA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of cAMP metabolic process [ISS]
- regulation of calcium ion import [IDA]
- regulation of cell proliferation [IMP]
- release of sequestered calcium ion into cytosol [IDA, IMP]
- renal artery morphogenesis [IEP]
- renal tubule morphogenesis [ISS]
- sodium ion transmembrane transport [IDA]
- spinal cord development [IEP]
Gene Ontology Molecular Function- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
- ATPase binding [ISS]
- HLH domain binding [IPI]
- actinin binding [IDA]
- calcium ion binding [ISS]
- calcium-induced calcium release activity [IDA]
- cytoskeletal protein binding [IDA]
- identical protein binding [IPI, ISS]
- ion channel binding [IPI]
- phosphoprotein binding [IPI]
- potassium channel activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- receptor binding [IPI]
- voltage-gated calcium channel activity [IDA]
- voltage-gated cation channel activity [IDA]
- voltage-gated ion channel activity [IDA]
- voltage-gated sodium channel activity [IDA]
Gene Ontology Cellular Component
- basal cortex [IDA]
- basal plasma membrane [IDA]
- cell-cell junction [ISS]
- ciliary basal body [IDA]
- cilium [ISS]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [IDA]
- integral component of plasma membrane [IDA]
- lamellipodium [IDA]
- mitotic spindle [IDA]
- motile primary cilium [ISS]
- nonmotile primary cilium [ISS]
- plasma membrane [IDA]
- polycystin complex [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.999987987 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999987987111409, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| C15ORF59 PKD2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8536 | BioGRID | 3029837 |
Curated By
- BioGRID