BAIT
ACVR2A
ACTRII, ACVR2
activin A receptor, type IIA
GO Process (10)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [IDA]
- cellular response to BMP stimulus [IMP]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MAGI2
ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (16)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISS]
- cellular response to nerve growth factor stimulus [ISS]
- cytoplasmic transport [ISS]
- glomerular visceral epithelial cell development [ISS]
- mitotic cell cycle arrest [ISS]
- negative regulation of activin receptor signaling pathway [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of protein kinase B signaling [IDA]
- nerve growth factor signaling pathway [ISS]
- planar cell polarity pathway involved in axis elongation [NAS]
- positive regulation of neuron projection development [ISS]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of receptor internalization [IDA]
- protein heterooligomerization [ISS]
- receptor clustering [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel factors in regulation of activin signaling.
Activin type II receptors (ActRIIs) are the primary receptors that transmit the activin signal to intracellular signaling pathways. Binding of activins to ActRIIs recruits the activin type I receptor and initiates downstream signaling. We have found that PDZ proteins, named activin receptor-interacting proteins (ARIPs), specifically associate with ActRIIs. We have studied the mechanism that ARIPs regulate cell surface expression and ... [more]
Mol. Cell. Endocrinol. Oct. 15, 2004; 225(1);1-8 [Pubmed: 15451561]
Throughput
- Low Throughput
Curated By
- BioGRID