BAIT

PSEN1

AD3, FAD, PS-1, PS1, S182
presenilin 1
UBI
GO Process (15)
GO Function (6)
GO Component (27)

External Database Linkouts

BioGRID ORCS | VEGA | HGNC | OMIM | Entrez Gene | RefSeq | UniprotKB | Ensembl | HPRD
Homo sapiens

PREY

YME1L1

FTSH, MEG4, PAMP, YME1L, RP11-145E8.2
YME1-like 1 ATPase
UBI
GO Process (3)
GO Function (0)
GO Component (2)

External Database Linkouts

BioGRID ORCS | VEGA | OMIM | HGNC | Entrez Gene | RefSeq | UniprotKB | Ensembl | HPRD
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2.

Pellegrini L, Passer BJ, Canelles M, Lefterov I, Ganjei JK, Fowlkes BJ, Koonin EV, D'Adamio L

The familial Alzheimer's disease gene products, presenilin-1 and presenilin-2 (PS1 and PS2), are involved in amyloid beta-protein precursor processing (AbetaPP), Notch receptor signaling, and programmed cell death. However, the molecular mechanisms by which presenilins regulate these processes remain unknown. Clues about the function of a protein can be obtained by seeing whether it interacts with another protein of known function. ... [more]

J. Alzheimers Dis. Apr. 01, 2001; 3(2);181-190 [Pubmed: 12214059]

Throughput

  • Low Throughput

Curated By

  • BioGRID