TH
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- catecholamine biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- dopamine biosynthetic process [IDA]
- dopamine biosynthetic process from tyrosine [NAS]
- embryonic camera-type eye morphogenesis [ISS]
- epinephrine biosynthetic process [IDA]
- eye photoreceptor cell development [ISS]
- heart development [ISS]
- heart morphogenesis [NAS]
- learning [ISS]
- locomotory behavior [ISS]
- memory [ISS]
- norepinephrine biosynthetic process [IDA]
- organ morphogenesis [ISS]
- pigmentation [TAS]
- regulation of heart contraction [ISS]
- response to ethanol [IDA]
- response to hypoxia [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, dopaminergic [ISS]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TAOK2
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- actin cytoskeleton organization [IDA]
- activation of MAPKK activity [IDA]
- apoptotic process [NAS]
- cell migration [NAS]
- cellular response to DNA damage stimulus [IDA]
- focal adhesion assembly [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein targeting to membrane [NAS]
- regulation of cell growth [NAS]
- regulation of cell shape [IDA]
- response to stress [IDA]
- stress-activated MAPK cascade [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999996 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999995800766, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TH TAOK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9945 | BioGRID | 2238430 | |
| TH TAOK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9834 | BioGRID | 3139747 |
Curated By
- BioGRID