BAIT
CHRNB2
EFNL3, nAChRB2, RP11-61L14.4
cholinergic receptor, nicotinic, beta 2 (neuronal)
GO Process (40)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- B cell activation [ISS]
- associative learning [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- central nervous system projection neuron axonogenesis [ISS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- lateral geniculate nucleus development [ISS]
- learning [IMP]
- locomotory behavior [ISS]
- membrane depolarization [ISS]
- memory [IMP]
- negative regulation of action potential [ISS]
- neurological system process [IMP]
- optic nerve morphogenesis [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of dopamine secretion [ISS]
- regulation of circadian sleep/wake cycle, REM sleep [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of dopamine secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic transmission, dopaminergic [ISS]
- response to cocaine [ISS]
- response to ethanol [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- sensory perception of pain [ISS]
- sensory perception of sound [ISS]
- signal transduction [IDA]
- smooth muscle contraction [ISS]
- social behavior [ISS]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [ISS]
- synaptic transmission, cholinergic [ISS]
- vestibulocochlear nerve development [ISS]
- visual learning [IMP]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EIF2AK3
PEK, PERK, WRS
eukaryotic translation initiation factor 2-alpha kinase 3
GO Process (26)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- ER overload response [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [IMP]
- bone mineralization [ISS]
- calcium-mediated signaling [ISS]
- cellular protein metabolic process [TAS]
- cellular response to glucose starvation [IMP]
- chondrocyte development [ISS]
- endocrine pancreas development [IMP]
- endoplasmic reticulum organization [ISS]
- endoplasmic reticulum unfolded protein response [IDA, TAS]
- insulin secretion [ISS]
- insulin-like growth factor receptor signaling pathway [ISS]
- negative regulation of myelination [ISS]
- negative regulation of translation [TAS]
- negative regulation of translational initiation in response to stress [TAS]
- ossification [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA, IMP]
- protein homooligomerization [IMP]
- protein phosphorylation [ISS]
- response to endoplasmic reticulum stress [IMP]
- skeletal system development [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.998366496 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.998366496008884, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNB2 EIF2AK3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 3030094 |
Curated By
- BioGRID