BAIT
YCS4
LOC7, YLR272C
Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
GO Process (9)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IMP]
- maintenance of rDNA [IMP]
- meiotic chromosome condensation [IMP]
- meiotic chromosome separation [IMP]
- mitotic chromosome condensation [IMP, IPI]
- mitotic sister chromatid segregation [IMP]
- negative regulation of meiotic DNA double-strand break formation [IMP]
- synaptonemal complex assembly [IMP]
- tRNA gene clustering [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SLX5
HEX3, ULS2, SUMO-targeted ubiquitin ligase complex subunit SLX5, L000000768, YDL013W
Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by SUMO-modified substrates; contains a RING domain and two SIM motifs; forms SUMO-dependent nuclear foci, including DNA repair centers; associates with the centromere; null mutants are aneuploid, have a metaphase delay, and spindle defects including: mispositioned spindles, fish hook spindles, and aberrant spindle kinetics; required for maintenance of genome integrity like human ortholog RNF4
GO Process (4)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Putting the brake on FEAR: Tof2 promotes the biphasic release of Cdc14 phosphatase during mitotic exit.
The completion of chromosome segregation during anaphase requires the hypercondensation of the approximately 1-Mb rDNA array, a reaction dependent on condensin and Cdc14 phosphatase. Using systematic genetic screens, we identified 29 novel genetic interactions with budding yeast condensin. Of these, FOB1, CSM1, LRS4, and TOF2 were required for the mitotic condensation of the tandem rDNA array localized on chromosome XII. ... [more]
Mol. Biol. Cell Jan. 01, 2009; 20(1);245-55 [Pubmed: 18923139]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID