YWHAZ
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MLXIPL
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- cellular response to carbohydrate stimulus [IBA]
- energy reserve metabolic process [TAS]
- fatty acid homeostasis [ISS]
- glucose homeostasis [ISS]
- glucose mediated signaling pathway [ISS]
- intracellular signal transduction [TAS]
- negative regulation of cell cycle arrest [IMP]
- negative regulation of oxidative phosphorylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cellular metabolic process [TAS]
- positive regulation of fatty acid biosynthetic process [ISS]
- positive regulation of glycolytic process [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- regulation of energy homeostasis [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [NAS]
- small molecule metabolic process [TAS]
- triglyceride homeostasis [NAS]
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999614271 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999614270964995, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| YWHAZ MLXIPL | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | 3536369 |
Curated By
- BioGRID